BI-6C9

BI-6C9

CAT N°: 17265
Price:

From 83.00 70.55

BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis.{28610,28613} BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.{28607,28608} It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation.{28611,28609} BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-?2a.{28612}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-butanamide
  • Correlated keywords
    • biochemical inhibitor mitochondrial biology apoptosis neuroscience cancer inhibit tBid t-Bid mediated BI6C9 truncated protein BH3-interacting domain
  • Product Overview:
    BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis.{28610,28613} BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.{28607,28608} It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation.{28611,28609} BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-?2a.{28612}

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