2-deoxy-D-Glucose-6-phosphate (sodium salt)

2-deoxy-D-Glucose-6-phosphate (sodium salt)

CAT N°: 17149
Price:

From 75.00 63.75

2-deoxy-D-Glucose (2-DG, Item No. 14325) is a synthetic analog of glucose used in cell metabolism and cancer research.{22664} 2-deoxy-D-Glucose-6-phosphate (2-DG6P) is a derivative of 2-DG. It is produced in mammalian cells by the action of hexokinase on 2-DG. The accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.{28214} However, the uptake of 2-DG by cells can be monitored in assays by the accumulation of 2-DG6P, which can be oxidized in vitro by glucose 6-phosphate dehydrogenase and reduce NADP+. In bacteria and yeast, 2-DG6P is metabolized to 2-DG by 2-DG6P phosphatase.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-(dihydrogen phosphate) 2-deoxy-D-arabino-hexose, monosodium salt
  • Correlated keywords
    • 33068-19-8 3573-50-0 288608-38-8 99469-20-2 76095-03-9 biochemical metabolism 2DGlu6P 2-deoxyglucose derivative 2-DG synthetic analog glucose metabolism cancer hexokinase inhibit glycolysis cell death
  • Product Overview:
    2-deoxy-D-Glucose (2-DG, Item No. 14325) is a synthetic analog of glucose used in cell metabolism and cancer research.{22664} 2-deoxy-D-Glucose-6-phosphate (2-DG6P) is a derivative of 2-DG. It is produced in mammalian cells by the action of hexokinase on 2-DG. The accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.{28214} However, the uptake of 2-DG by cells can be monitored in assays by the accumulation of 2-DG6P, which can be oxidized in vitro by glucose 6-phosphate dehydrogenase and reduce NADP+. In bacteria and yeast, 2-DG6P is metabolized to 2-DG by 2-DG6P phosphatase.

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