Cu-ATSM

Cu-ATSM

CAT N°: 17122
Price:

48.00 40.80

Cu-ATSM is a copper-containing compound with diverse biological activities.{49720,30772,30773} It inhibits ferroptotic cell death induced by RSL3, erastin (Item No. 17754), or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells when used at a concentration of 1 µM.{49720} Cu-ATSM (30 mg/kg per day) increases mutant superoxide dismutase (SOD1G37R) protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of amyotrophic lateral sclerosis (ALS).{30772} It also increases the number of ?-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model. Cu-ATSM containing positron-emitting copper isotopes has been used in PET imaging applications for selective labeling of hypoxic tissue.{30773}

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