SB-224289 (hydro<wbr>chloride)

SB-224289 (hydrochloride)

CAT N°: 17036
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From 85.00 72.25

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-224289 is a potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors.{27920} It has been used to study the role of 5-HT1B receptors in cocaine self-administration and cocaine-seeking behavior.{27921}

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