TAK-733

TAK-733

CAT N°: 16998
Price:

From 49.00 41.65

TAK-733 is an inhibitor of MEK1 (IC50 = 3.2 nM), a MAP kinase in the Raf/MEK/ERK pathway that plays a major role in the regulation of cellular growth, differentiation, and proliferation.{37319},{17156} It is selective for MEK1 over a panel of 18 kinases, receptors, and ion channels up to a concentration of 10 µM. TAK-733 inhibits ERK phosphorylation in vitro (EC50 = 1.9 nM). It also inhibits proliferation of A375 and COLO 205 cells (EC50s = 3.1 and 2.1 nM, respectively) and 14 cutaneous melanoma cell lines (IC50s = V600E mutations.{37319},{37320} TAK-733 has antitumor activity in mouse xenograft models using a variety of cancer types.{37319}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
  • Correlated keywords
    • 1035555-64-6 TAK733 MEK-1 anti-tumor A-375 COLO205 BRAFV600E braf b-raf-v600e
  • Product Overview:
    TAK-733 is an inhibitor of MEK1 (IC50 = 3.2 nM), a MAP kinase in the Raf/MEK/ERK pathway that plays a major role in the regulation of cellular growth, differentiation, and proliferation.{37319},{17156} It is selective for MEK1 over a panel of 18 kinases, receptors, and ion channels up to a concentration of 10 µM. TAK-733 inhibits ERK phosphorylation in vitro (EC50 = 1.9 nM). It also inhibits proliferation of A375 and COLO 205 cells (EC50s = 3.1 and 2.1 nM, respectively) and 14 cutaneous melanoma cell lines (IC50s = V600E mutations.{37319},{37320} TAK-733 has antitumor activity in mouse xenograft models using a variety of cancer types.{37319}

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