Binimetinib

Binimetinib

CAT N°: 16996
Price:

From 85.00 72.25

Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM).{27962} It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ? 5 nM).{27962} This compound is efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-RAF mutations, and has been characterized in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer.{27962,27963,27940}

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