BRD73954

BRD73954

CAT N°: 16919
Price:

From 122.00 103.70

BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively).{27579} It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 µM, respectively). BRD73954 (10 µM) increases acetylation of ?-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
  • Correlated keywords
    • BRD-73954 H HDAC 1 2 3 4 5 6 7 8 He La ?tubulin
  • Product Overview:
    BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively).{27579} It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 µM, respectively). BRD73954 (10 µM) increases acetylation of ?-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.

We also advise you