17-<wbr/>trifluoromethylphenyl trinor Prostaglandin F<sub>2?</sub>

17-trifluoromethylphenyl trinor Prostaglandin F2?

CAT N°: 16890
Price:

From 92.00 78.20

A number of 17-phenyl trinor prostaglandin F2? (17-phenyl trinor PGF2?) derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.{9668} 17-trifluoromethylphenyl trinor PGF2? bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2? would act very much like the free acid of travoprost. 17-phenyl trinor PGF2? is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.{9668}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9?,11?,15S-trihydroxy-17-trifluoromethylphenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid
  • Correlated keywords
    • 17-trifluoromethylphenyl-trinor-PGF2.alpha. agonists glaucoma 17-trifluoromethylphenyl-trinor-PGF2alpha analogs FP intraocular pressure iop receptors prostaglandins ophthalmology
  • Product Overview:
    A number of 17-phenyl trinor prostaglandin F2? (17-phenyl trinor PGF2?) derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.{9668} 17-trifluoromethylphenyl trinor PGF2? bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2? would act very much like the free acid of travoprost. 17-phenyl trinor PGF2? is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.{9668}

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