IPI-145

IPI-145

CAT N°: 16800
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From 102.00 86.70

IPI-145 is a potent inhibitor of the phosphoinositide 3-kinase (PI3K) isoforms PI3K? and PI3K? (IC50s = 0.24 and 50 nM, respectively).{27763} It is orally bioavailable and selective.{27763} As PI3K? and PI3K? are preferentially expressed in immune cells, IPI-145 has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models.{27763,27764} It also has potential applications in immunotherapy and in certain cancers.{27762,27761}

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