P7C3

P7C3

CAT N°: 16682
Price:

From 157.00 133.45

P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus.{27449} At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury.{27447,27448} While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.{27340}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,6-dibromo-?-[(phenylamino)methyl]-9H-carbazole-9-ethanol
  • Correlated keywords
    • neural stem cells neuroprotection neuron neurodengeneration nerve injury NAMPT NAD Alzheimer?s disease research Parkinson’s neuroscience biology biochemical proneurogenic neuroprotective compound P7-C3 P-7C3 P7C-3 P-7-C-3 orally bioavailable brain penetrant aminopropyl carbazole preventing apoptosis postmitotic subgranular zone hippocampal dentate gyrus promote survival rodent model bind nicotinamide phosphoribosyltransferase rate-limiting enzyme conversion adenine dinucleotide
  • Product Overview:
    P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus.{27449} At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury.{27447,27448} While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.{27340}

We also advise you