Tizanidine (hydrochloride)

Tizanidine (hydrochloride)

CAT N°: 16477
Price:

From 92.00 78.20

Tizanidine is an ?2-adrenergic receptor (?2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective ?2-AR antagonist RX781094 but not the ?1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits ?- and ?-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine, monohydrochloride
  • Correlated keywords
    • 51322-75-9 Sirdalud Ternelin Tizan Tizpa Zanaflex AB 021 AB021 21 AB21 AN021 AN21 AN DS103282 103282 WB4101 RX-781094 ?2AR
  • Product Overview:
    Tizanidine is an ?2-adrenergic receptor (?2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective ?2-AR antagonist RX781094 but not the ?1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits ?- and ?-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}

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