α-(difluoromethyl)-DL-Arginine

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 2-(difluoromethyl)-arginine
• Correlated keywords
  • polyamines biosynthesis inhibitors plants growths regulators putrescines immunology infectious diseases arginines decarboxylases 77286-88-5 signals transductions cells biology biochemicals DL-?-(Difluoromethyl)arginine ?-Difluoromethylarginine ? enzymes activated enzyme-activated irreversible irreversibly inhibits E Escherichia coli Ecoli P Pseudomonas aeruginosa Paeruginosa K Klebsiella pneumonia Kpneumonia prevents prevention osmotic stress-induced stress induced increases activities activity synthesis oats leaf reduces reductions reduced T Trypanosoma cruzi Tcruzi mammalian mammals hosts C. Cryptosporidium parvum Cparvum T-cells Tcells receptors ?-deficient deficient mouse models polyamines analogs RMI 71897
• Product Overview:
  Bacteria synthesize the cellular growth factor putrescine through a number of pathways. One pathway involves the decarboxylation of arginine by arginine decarboxylase to produce agmatine, which is then degraded to putrescine. While important for various cellular processes (e.g., cell division, differentiation, environmental stress responses) in all living organisms, including plants, high levels of this polyamine can be toxic.{23742} ?-(difluoromethyl)-DL-Arginine (DFMA) is an enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 µM), P. aeruginosa, and K. pneumoniae.{26879} At 0.01 mM, it has been shown to prevent the osmotic stress-induced increase in arginine decarboxylase activity and putrescine synthesis in oat leaf cells.{26875,26878} DFMA can also reduce the growth of T. cruzi in mammalian host cells at a minimal concentration of 10 mM and prevent the growth of C. parvum in a T cell receptor alpha-deficient mouse model when combined with various polyamine analogs.{26877,26876}