UNC0379

UNC0379

CAT N°: 16400
Price:

From 140.00 119.00

SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379 is a substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC50 = 7.3 µM; Kd = 18.3 µM).{26523} It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC50s = >100 µM).{26523}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine
  • Correlated keywords
    • SET domain-containing protein 8 SET8 SETD8 lysine methyltransferase histone H4 at lysine residue 20 inhibitor epigenetics cancer biochemical inhibit MTase KTMase SET-8 SET-D8 UNC-0379
  • Product Overview:
    SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379 is a substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC50 = 7.3 µM; Kd = 18.3 µM).{26523} It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC50s = >100 µM).{26523}

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