XL888

XL888

CAT N°: 16309
Price:

From 74.00 62.90

Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.{18248} XL888 is an ATP-competitive inhibitor of Hsp90.{28107} Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis.{28108,28110,28109} XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice.{28107,28110}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N1-[(3-endo)-8-[5-(cyclopropylcarbonyl)-2-pyridinyl]-8-azabicyclo[3.2.1]oct-3-yl]-2-methyl-5-[[(1R)-1-methylpropyl]amino]-1,4-benzenedicarboxamide
  • Correlated keywords
    • biochemical inhibitor cancer intracellular signaling heat shock protein apoptosis cell cycle inhibit HSP90 HSP 90 chaperone client ATP competitive XL-888 degrade arrest oral bioavailable tumor regression gastric carcinoma melanoma xenograft
  • Product Overview:
    Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.{18248} XL888 is an ATP-competitive inhibitor of Hsp90.{28107} Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis.{28108,28110,28109} XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice.{28107,28110}

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