GW 788388

GW 788388

CAT N°: 16255
Price:

From 85.00 72.25

GW 788388 is a selective inhibitor of transforming growth factor-? (TGF-?) type 1 receptor (TGFBR1 or ALK5; IC50 = 18 nM).{27870} It inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day.{27870} As TGF-? stimulates fibrosis in a range of tissues, GW 788388 reduces typical features of fibrosis, including tissue remodeling, increased expression of ?-smooth muscle actin and production of collagen I.{27872,27874,27875} GW 788388 also blocks TGF-?-mediated production of VEGF by fibroblasts, as well as subsequent angiogenesis in vitro.{27873} Inhibition of ALK5 signaling by GW 788388 also induces hypertrophy in femoral growth plates in rats.{27871}

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