Foretinib

Foretinib

CAT N°: 16249
Price:

From 48.00 40.80

Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFR?, and Tie-2, at nanomolar concentrations.{32583,24156} It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing HGF-induced responses in tumor cells and HGV/VEGF-induced responses in endothelial cells.{32583,23657} Foretinib is functional in vivo, reducing tumor burden in an experimental model of lung metastasis.{32583}

We also advise you