MAZ51

MAZ51

CAT N°: 16168
Price:

From 74.00 62.90

The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis.{26699} MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2.{27479} It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFR?.{27480} By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA.{27477} It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo.{27480} MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.{27478,27476}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-2H-indol-2-one
  • Correlated keywords
    • biochemical cancer angiogenesis receptor antagonist apoptosis signal transduction protein kinase VEGFR-3 FLT-4 VEGFR3 FLT4 VEGF MAZ-51 signaling VEGF-R3 isoform VEGF-C VEGFC VEGF-D VEGFD lymphatic endothelial cell lymphangiogenesis indoline antagonizes activation VEGFR-2 VEGFR2 autocrine loop induced expression ligand VEGF-A VEGFA reduce proliferation in vitro suppress tumor growth in vivo function survival
  • Product Overview:
    The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis.{26699} MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2.{27479} It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFR?.{27480} By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA.{27477} It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo.{27480} MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.{27478,27476}

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