Seco Rapamycin (sodium salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • [2R-[2?,2(S*),3?,6?[2S*,3E,5E,7E,9S*,11R*,13R*,14R*,15E,7R*,19E,21R*,22(1S*,3R*,4R*)]]]-1-[oxo[tetrahydro-2-hydroxy-6-[14-hydroxy-22-(4-hydroxy-3methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaenyl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic acid, monosodium salt
• Correlated keywords
  • 147438-27-5 intracellular signaling inhibitors cells biology signals inhibits inhibitions degradations degrades products natural macrolides immune systems immunosuppressants activates activations mTORC1 nonenzyme-dependents nonenzymes dependents rapamycins esters hydrations hydrates dehydrations thymocytes proliferations assays kits proliferates ring-opened rings opened cytoplasms homogenates Caco-2 caco2 caco 2 Caco-two cacotwo caco two Caco-II cacoII caco II cells secreted secretes secretions p-glycoproteins pglycoproteins p glycoproteins metabolizes metabolisms metabolized dihydro species mTOR proteasomes mammalian targets of complex complexes 1 I one
• Product Overview:
  Rapamycin (Item No. 13346) is a natural macrolide immunosuppressant that activates mTORC1. Seco rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin (Item No. 13346) resulting from ester hydration followed by dehydration.{26501} It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay.{26501} Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells.{26499} Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species.{26500} While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.{26502}