Zoniporide (hydro<wbr>chloride)

Zoniporide (hydrochloride)

CAT N°: 16004
Price:

From 55.00 46.75

The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.{22706} It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms.{25880} It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.{22706} In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.{25880}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide, monohydrochloride
  • Correlated keywords
    • 241800-98-6 sodium-hydrogen sodiums hydrogens isoforms 1 one exchangers isoform-1 NHE-1 Na+/H+ NHE cardioprotection selective inhibits inhibitions inhibitors NHE1 reduces reductions reducing infarct sizes rabbits myocardial ischemia reperfusion hemodynamics cardiac functions CPs 597396 CP-597396 CP597396 ions channels pumps blockers cardiology sodium/hydrogen ischemia-reperfusion hearts HCl
  • Product Overview:
    The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.{22706} It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms.{25880} It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.{22706} In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.{25880}

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