Clonidine (hydro<wbr>chloride)

Clonidine (hydrochloride)

CAT N°: 15949

Clonidine is an agonist of ?2-adrenergic receptors (?2-ARs; Kis = 61.66, 69.18, and 134.9 nM for ?2A-, ?2B-, and ?2C-ARs, respectively).{40326} It stimulates [35S]GTP?S binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for ?2A-, ?2B-, and ?2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).{46373} It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 ?M.{25849} Clonidine (10 ?M) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 ?g/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} Formulations containing clonidine have been used in the treatment of hypertension.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride
  • Correlated keywords
    • 4205-90-7 7555-?15-?9 57665-?50-?6 64638-?22-?8 66009-?47-?0 66073-?52-?7 73121-?65-?0 antihypertensive anti anti-hypertensive hypertensive imidazoline receptors I1 HCl ST 155 ST155 ST-155 nexiclon K+ potassium Kapvay Catapres ?2A 2B 2C 35-S HEK-293 I-1
  • Product Overview:
    Clonidine is an agonist of ?2-adrenergic receptors (?2-ARs; Kis = 61.66, 69.18, and 134.9 nM for ?2A-, ?2B-, and ?2C-ARs, respectively).{40326} It stimulates [35S]GTP?S binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for ?2A-, ?2B-, and ?2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).{46373} It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 ?M.{25849} Clonidine (10 ?M) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 ?g/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} Formulations containing clonidine have been used in the treatment of hypertension.

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