MK2 Inhibitor III

MK2 Inhibitor III

CAT N°: 15943
Price:

From 109.00 92.65

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation.{22830,17013,22949} MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM).{25966} It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets.{25966} MK2 inhibitor III prevents LPS-induced synthesis of TNF-? in human monocyte-like U937 cells (IC50 = 4.4 µM).{25966}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1,5,6,7-tetrahydro-2-[2-(3-quinolinyl)-4-pyridinyl]-4H-pyrrolo[3,2-c]pyridin-4-one, monohydrate
  • Correlated keywords
    • 724711-21-1 inhibitors kinases proteins signals transduction intracellulars signaling inflammation MKs 2 two MK-2 III inhibits inhibitions potent cells permeable cell-permeable MAPs kinase-activated activated MAPKAP2 MAPKAP-2 MAPKAP mitogen-activated mitogen activated MK3 MK-3 3 three MK5 MK-5 5 five TNF-? TNF-a TNF-alpha TNF-.alpha.
  • Product Overview:
    MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation.{22830,17013,22949} MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM).{25966} It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets.{25966} MK2 inhibitor III prevents LPS-induced synthesis of TNF-? in human monocyte-like U937 cells (IC50 = 4.4 µM).{25966}

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