Territorial Availability: Available through Bertin Technologies only in France
- Synonyms
- 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, monohydrochloride
- Correlated keywords
- anti-depressant ACTH 50-49-7 HCl Apo-Imipramine Censtim Censtin Chrytemin DIPD Deprinol Depsol Dimipressin Dyna-Zina Efuranol Eupramin Feinalmin G 22355 G22355 Imavate Imidobenzyle Imidol Imilanyle monohydrochloride Imiprin Imizin Imizine Imizinum Impril Intalpram Iramil Irmin Janimine Novo-pramine Praminil Presamine Promiben Pryleugan SK-Pramine Surplix Teperine Timolet Tipramine Tofranile N-(3-Dimethylaminopropyl)iminodibenzyl N-(?-Dimethylaminopropyl)iminodibenzyl surface glycoprotein Tofranil Melipramin SARSCoV2 SARSCoV 2 5HT ppVSV
- Product Overview:
Imipramine is a first generation tricyclic antidepressant.{25873} It inhibits serotonin (5-HT) uptake by isolated human platelets by 54 and 79% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 63% when administered at a dose of 20 mg/kg.{61584,61585} It also binds to histamine H1, M1 muscarinic acetylcholine, and ?1-adrenergic receptors (Kds = 37, 46, and 32 nM, respectively).{25803} Imipramine (10 and 20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681).{54655} Formulations containing imipramine have been used in the treatment of depression and as an adjunct in the treatment of childhood enuresis.
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.