Amitriptyline (hydrochloride)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride
• Correlated keywords
  • 50-48-6 8058-?15-?9 neurosciences inhibitors receptors antagonists signals transduction tricyclic antidepressants serotonin norepinephrine transporters inhibits inhibitions 5-HT2A antagonizes histamine H1 muscarinic acetylcholine ?1- adrenergic alpha1- adrenergic .alpha.1- adrenergic a1- adrenergic HCl adepril amicen amil 25 amilent amilit amineurin amiplin amiprin amitid amitril amitrip chlorides amyline amyzol anapsique apo-amitriptyline damilen deprex elatrol elatrolet enafon etravil euplit lantron laroxyl larozyl lentizol miketorin NIH 10794 NIH10794 NIH-10794 noriline novoprotect pinsanu pinsaun redomex Ro 4-1575 saroten retard sarotena sarotex sylvemid syneudon teperin trepiline tridep tripta triptizol trynol tryptal tryptanol tryptine tryptizol trytomer uxen vanatrip Domical Elavil Endep Saroten
• Product Overview:
  Amitriptyline is a first generation tricyclic antidepressant.{25873} It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 77% when administered at a dose of 10 mg/kg.{61584,61585} It is also an antagonist of the 5-HT receptor subtype 5-HT2A (Ki = 20 nM), as well as histamine H1, muscarinic acetylcholine, and ?1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).{25919,25914,25803} Amitriptyline (5-25 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681) or recombinant human acid sphingomyelinase.{54655} Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Item Nos. 19029 | 19031).