MreB Perturbing Compound A22

MreB Perturbing Compound A22

CAT N°: 15870
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109.00 92.65

MreB is an actin-like protein expressed in bacteria.{25735} It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity.{25734} MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly.{25730} It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml).{25731} It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes.{25730} In V. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.{25733}

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