Voriconazole

Voriconazole

CAT N°: 15633
Price:

From 123.00 104.55

Voriconazole is a triazole antifungal agent and a derivative of fluconazole (Item No. 11594).{48762,48763} It is active against a variety of yeast and fungi, including clinical isolates of A. flavus, A. fumigatus, F. oxysporum, F. solani, C. albicans, and C. neoformans (MICs = C. albicans (MICs = 0.015-8 µg/ml).{48763} It inhibits ergosterol biosynthesis in C. albicans, C. glabrata, A. fumigatus, and A. flavus (IC50s = 0.03-1 µg/ml).{24400} Voriconazole (10 mg/kg twice per day, i.v.) decreases the number of lung colony-forming units (CFUs), reduces alveolar collapse and lung inflammatory cell infiltration and necrosis, and increases survival in a rat model of invasive pulmonary aspergillosis.{48764} Formulations containing voriconazole have been used in the treatment of fungal infections.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (?R)-?-(2,4-difluorophenyl)-5-fluoro-?S-methyl-?-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
  • Correlated keywords
    • 173967-?54-?9 triazoles antifungals anti-fungals anti fungals inhibitors inhibits inhibitors yeasts Candida fungi Aspergillus Scedosporium Fusarium ergosterol synthesis agents pathogenic filamentous infectious diseases DRG0301 DRG-0301 DRGs 0301 UKs 109496 UK109496 UK-109496 VRC vfend voriconazol voriconazole 17803 Vfend
  • Product Overview:
    Voriconazole is a triazole antifungal agent and a derivative of fluconazole (Item No. 11594).{48762,48763} It is active against a variety of yeast and fungi, including clinical isolates of A. flavus, A. fumigatus, F. oxysporum, F. solani, C. albicans, and C. neoformans (MICs = C. albicans (MICs = 0.015-8 µg/ml).{48763} It inhibits ergosterol biosynthesis in C. albicans, C. glabrata, A. fumigatus, and A. flavus (IC50s = 0.03-1 µg/ml).{24400} Voriconazole (10 mg/kg twice per day, i.v.) decreases the number of lung colony-forming units (CFUs), reduces alveolar collapse and lung inflammatory cell infiltration and necrosis, and increases survival in a rat model of invasive pulmonary aspergillosis.{48764} Formulations containing voriconazole have been used in the treatment of fungal infections.

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