Ophiobolin A

Ophiobolin A

CAT N°: 15381
Price:

From 414.00 351.90

Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions.{23722,24947} Ophiobolin A is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, blocking the activation of calmodulin-dependent phosphodiesterase with an IC50 value of 9 ?M.{24945} It antagonizes a variety of forms of calmodulin from plants and animals by binding covalently to conserved lysine residues.{24948,24946}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2’S,3’S,3aR,5’R,6aS,9R,9aS,10aR)-1,3a,4,4′,5′,6a,7,8,9,9a,10,10a-dodecahydro-9-hydroxy-3′,9,10a-trimethyl-5′-spiro[dicyclopenta[a,d]cyclooctene-3(2H),2′(3’H)-furan]-6-carboxaldehyde
  • Correlated keywords
    • 1347-?57-?5 5843-?70-?9 11022-?22-?3 17046-?71-?8 natural products inhibitors signals transductions intracellular signaling inhibits inhibitions calmodulin antagonists sesterterpenoid fungal phytotoxins plants animals NSCs 114340 NSC114340 NSC-114340 calmodulin-dependent phosphodiesterases ophiobalin bipolaris leersia
  • Product Overview:
    Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions.{23722,24947} Ophiobolin A is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, blocking the activation of calmodulin-dependent phosphodiesterase with an IC50 value of 9 ?M.{24945} It antagonizes a variety of forms of calmodulin from plants and animals by binding covalently to conserved lysine residues.{24948,24946}

We also advise you