Ginsenoside Rb₁

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 20-[(6-O-?-D-glucopyranosyl-?-D-glucopyranosyl)oxy]-12?-hydroxydammar-24-en-3?-yl 2-O-?-D-glucopyranosyl-?-D-glucopyranoside
• Correlated keywords
  • 12770-?17-?1 52286-?61-?0 87700-?07-?0 212055-?66-?8 393829-?67-?9 natural products neurosciences inflammation obesity apoptosis ginesosides ginseng plants genus panax protopanaxadiol species P. quinquefolium in vitro vivo neuroprotective anti-inflammatory anti inflammatory antiinflammatory anti-obesity obesity antiobesity steroids Rb1 arasaponin E1 gynosaponin C gypenoside III NSCs 310103 NSC-310103 NSC310103 notoginsenoside panaxoside sanchinoside glycosides triterpenes squalene p-38 A?-40 NF?B
• Product Overview:
  Ginsenoside Rb1 is a triterpene saponin that has been found in P. ginseng and has diverse biological activities.{24876,24875,67161,67162,67163} It decreases apoptosis and increases in protein kinase A (PKA), PKC, caspase-3, and caspase-9 levels induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes when used at a concentration of 100 µM.{24876} Ginsenoside Rb1 (1 µM) inhibits glucose-induced cytotoxicity and production of reactive oxygen species (ROS) in primary rat hippocampal neurons.{24875} It inhibits LPS-induced activation of IL-1 receptor-associated kinase 1 (IRAK1), I???, NF-?B, as well as the MAP kinases ERK, JNK, and p38, in mouse peritoneal lavage fluid when used at a concentration of 100 µM.{67162} Ginsenoside Rb1 (10 mg/kg for 30 days) increases hippocampus nestin and glial fibrillary acidic protein (GFAP) levels, markers of neural stem cells and astrocytes respectively, in a rat model of Alzheimer’s disease induced by amyloid-? (1-40) (A?40).{67161} It decreases high-fat diet-induced increases in liver weight, hepatic triglyceride accumulation, serum fasting glucose levels, and serum LDL levels in a mouse model of obesity when administered at a dose of 200 mg/kg per day.{67163}