Disulfiram

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Dangerous Good in said quantity, not available for sale.

• Synonyms
  • N,N,N’,N’-tetraethyl-thioperoxydicarbonic diamide
• Correlated keywords
  • 155-?01-?1 11078-?22-?1 Antabuse Antabus alcoholism alcohol abuse dependence metabolism anti-cancer anti cancers anticancers metal chelator copper zinc 20S proteasome 26S proteasome cocaine inhibitors inhibits inhibitions aldehydes dehydrogenase dopamine ?-hydroxylase irreversible b-hydroxylase beta-hydroxylase .beta.-hydroxylase MDA-MB-0231 MDAMB0231 MDA MB 0231 breast reactive oxygen species ROS JNK p38 NF-kB NF-?B NF-kappaB NF-.kappa.B stem cells abstensil abstinil abstinyl accel TET TET-R TETR R akrochem TETD alcophobin antadix antaethyl antalcol antetan antetil anticol antietanol antietil antikol antivitium aversan averzan contralin cronetal dicupral ekagom DTET TEDS TETDS espenal etabus ethyl thiram thiurad tuads tuex etiltox exhoran exhorran hoca krotenal tetraethyldithiuram disulfide NSCs 25953 NSC-25953 NSC25953 nocceler TET-G TETG G noxal refusal sanceler soxinol stopetyl TTs tetradin tetradine tetraethyldithiuram tetraethylthioperoxydicarbonic diamide tetraethylthiram tetraethylthiuram tetraetil teturam teturamin thiuram E thiuranide
• Product Overview:
  Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM).{25186} It also inhibits the copper-dependent enzyme dopamine ?-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence.{25185} When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 ?M) and 26S proteasome (IC50 = 20 ?M) from MDA-MB-0231 breast cancer cells.{25183,25182} Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-?B activity, which suppresses self-renewal in cancer stem cells.{25187,25184}