9-<wbr/>Phenanthrol

9-Phenanthrol

CAT N°: 15248
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From 74.00 62.90

9-Phenanthrol is an inhibitor of transient receptor potential melastatin 4 (TRPM4; IC50s = 19.1, 17.1, and 22.8 µM at +40, -40, and -80 mV, respectively, in HEK293 cells expressing the human receptor).{57698} It is selective for TRPM4 over TRPM5 at 100 µM. 9-Phenanthrol (100 µM) reduces heart rate in spontaneously beating isolated mouse right atria.{57699} It reduces infarct size and apoptosis in isolated rat hearts in an ex vivo model of ischemia-reperfusion injury.{57700} In vivo, 9-phenanthrol reduces myogenic tone in rat cerebral arteries.{57701}

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