ZD 7288

ZD 7288

CAT N°: 15228
Price:

From 102.00 86.70

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to native pacemaker currents in heart and neurons and modulate cardiac and neuronal excitability.{28047} Certain HCN channels also accentuate neuropathic pain.{28043} ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively).{28045} Through its effects on HCN channels, ZD 7288 modulates the sinoatrial node and slows heart rate.{28049,28044} In addition, ZD 7288 reduces neuropathic pain in several animal models.{28046,28048}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine, monohydrochloride
  • Correlated keywords
    • 133060-80-7 133061-?00-?4 150045-?15-?1 151964-?24-?8 biochemical ion channel blocker pain cardiology neuroscience ZD7288 ZD-7288 HCN HCN1 potassium sodium hyperpolarization cyclic nucleotide pacemaker heart neuron cardiac neuropathic inhibit inhibition inhibitor HCN4 sinoatrial node rate ICI-D7288 ICI-D-7288 ICID 7288 ICID7288
  • Product Overview:
    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to native pacemaker currents in heart and neurons and modulate cardiac and neuronal excitability.{28047} Certain HCN channels also accentuate neuropathic pain.{28043} ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively).{28045} Through its effects on HCN channels, ZD 7288 modulates the sinoatrial node and slows heart rate.{28049,28044} In addition, ZD 7288 reduces neuropathic pain in several animal models.{28046,28048}

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