ML-<wbr/>090

ML-090

CAT N°: 15172
Price:

From 48.00 40.80

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer.{24571} ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ? 10 µM) and xanthine oxidase (IC50 = 3.5 µM).{24571}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5,12-dihydro-quinoxalino[2,3-b]quinoxaline
  • Correlated keywords
    • molecular library initiatives NADPH oxidase 1 NOX1 CID 616479 inhibitors inhibits inhibitions NOXs NOX-1 one 1 MLs ML090 090 specific HEK293 HEK-293 HEKs 293 quinoxaline scaffolds xanthine ROS inflammatory bowels diseases IBD prostates cancers fluoflavine 55977-58-7 reactive oxygen species
  • Product Overview:
    NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer.{24571} ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ? 10 µM) and xanthine oxidase (IC50 = 3.5 µM).{24571}

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