Monastrol

Monastrol

CAT N°: 15044
Price:

From 102.00 86.70

Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 ?M).{8354,24107} It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes.{24106} Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines.{22151}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
  • Correlated keywords
    • 254753-54-3 inhibitors cells cycling cancers cell-permeable permeable motor proteins Eg5 kinesin family 11 Kif11 Kif-11 Kif 11 ATPases in vitro arrests mitosis induces inducer mitotic arrest death tumors reversible monoastral spindles microtubule assembly checkpoint cycles
  • Product Overview:
    Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 ?M).{8354,24107} It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes.{24106} Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines.{22151}

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