PF-<wbr/>04708671

PF-04708671

CAT N°: 15018
Price:

From 140.00 119.00

P70 ribosomal S6 kinase (S6K1) is a serine/threonine kinase which is activated by insulin and growth factors through PI3K and mTORC1 signaling pathways. PF-04708671 is a specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM).{22617} It does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity.{22617} It is useful in evaluating the role of S6K1 and, indirectly, mTORC1, in cell signaling.{22618,22616}

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