PF-<wbr/>04418948

PF-04418948

CAT N°: 15016
Price:

From 148.00 125.80

Prostaglandin E2 (PGE2) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP2 is a G protein-coupled receptor which signals preferentially through Gs proteins. PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).{22584} It is over a thousand-fold less active at other prostanoid receptors, including other EP receptors. PF-04418948 can be used in cells and tissues.{22583,22585} In rats, it significantly reduces the effects of the EP2-selective agonist butaprost on cutaneous blood flow when given orally.{22584}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
  • Correlated keywords
    • receptors antagonists vascular diseases neurosciences immunology inflammation cancers PF04418948 PF 04418948 PF-04418948 orally oral active potent selectives EP2 E prostanoids EPs antagonists cells tissues reduces EP2-selective agonists butaprost blood flows PGs prostaglandins PGE2 E2 G protein-coupled GPCRs GS proteins signals signaling rats cutaneous
  • Product Overview:
    Prostaglandin E2 (PGE2) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP2 is a G protein-coupled receptor which signals preferentially through Gs proteins. PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).{22584} It is over a thousand-fold less active at other prostanoid receptors, including other EP receptors. PF-04418948 can be used in cells and tissues.{22583,22585} In rats, it significantly reduces the effects of the EP2-selective agonist butaprost on cutaneous blood flow when given orally.{22584}

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