Exemestane

Exemestane

CAT N°: 15008
Price:

From 66.00 56.10

Exemestane is a third generation, irreversible steroidal aromatase inhibitor (Ki = 10.2 nM; Kinact = 26 nM) that induces aromatase degradation leading to a decrease in estrogen levels in plasma.{22655,22657} As an androgen analog, exemestane exhibits androgenic effects and has been shown to decrease total and HDL cholesterol, apo A1, and total triglyceride levels.{22656} Marketed under the trade name Aromasin™, exemestane has been used to treat estrogen receptor-positive breast cancers in post-menopausal women.{22655}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-methylene-androsta-1,4-diene-3,17-dione
  • Correlated keywords
    • steroids endocrinology inhibitors cancers aromasin aromatases breasts estrogens third 3rd generations steroidal inhibits inhibitions induces degradations decreases plasma lower HDL cholesterols apo A1 apo-A1 apoA1 triglycerides postmenopausal post-menopausal posts menopausal aromasil FCE24304 FCE 24304 FCE-24304 irreversible levels androgens analogs androgenics effects high-density high density lipoproteins total receptor-positive receptors positives
  • Product Overview:
    Exemestane is a third generation, irreversible steroidal aromatase inhibitor (Ki = 10.2 nM; Kinact = 26 nM) that induces aromatase degradation leading to a decrease in estrogen levels in plasma.{22655,22657} As an androgen analog, exemestane exhibits androgenic effects and has been shown to decrease total and HDL cholesterol, apo A1, and total triglyceride levels.{22656} Marketed under the trade name Aromasin™, exemestane has been used to treat estrogen receptor-positive breast cancers in post-menopausal women.{22655}

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