(–)-<wbr/>Thalidomide

(–)-Thalidomide

CAT N°: 14967
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From 83.00 70.55

(–)-Thalidomide is an active enantiomer of (±)-thalidomide (Item No. 14610) and has immunomodulatory and teratogenic activities.{54270,54271,54272} It enhances TNF-? production induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells when used at concentrations ranging from 0.1 to 100 µM.{54270} Preincubation of isolated Rhode Island Red (RIR) chicken donor blood with (–)-thalidomide (10 mg/ml) reduces recipient chicken embryo splenomegaly in a model of graft versus host disease.{54271} (–)-Thalidomide (150 mg/kg) induces fetal malformations when administered to pregnant female rabbits.{54272}

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