CUR 61414

CUR 61414

CAT N°: 14931
Price:

From 180.00 153.00

CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM).{24330,24331} It binds directly with the pathway activator Smoothened (Ki = 44 nM).{20488} CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.{24330,24332}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide
  • Correlated keywords
    • 570431-20-8 inhibitors signal transduction cancers receptor antagonists inhibits inhibitions CUR61414 CUR-61414 CURs 61414 potent hedgehogs HH hedgehog-induced induced activity active cellular binds binders bindings pathway smoothened activator Smo smooth proliferation basal carcinoma regression basaloid lesions ultraviolet lights skin Gs 856 G856
  • Product Overview:
    CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM).{24330,24331} It binds directly with the pathway activator Smoothened (Ki = 44 nM).{20488} CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.{24330,24332}

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