Loperamide (hydro<wbr>chloride)

Loperamide (hydrochloride)

CAT N°: 14875
Price:

Loperamide is an opiate which potently and selectively activates ? opioid receptors (Ki = 0.16 nM) exclusively in the periphery. Loperamide is an opiate which potently and selectively activates ? opioid receptors (Ki = 0.16 nM) exclusively in the periphery.{23761,23758} It is a much weaker agonist of the ? opioid receptor (Ki = 50 nM).{23761} Through its actions in the gut wall, loperamide has antidiarrheal action by increasing transit time and by altering intestinal transport of water and electrolytes.{23758,23756} It also blocks voltage-sensitive sodium channels (IC50 = 270 nM) and high voltage-activated calcium channels (IC50 = 900 nM), presumably through an inhibitory effect on calmodulin.{23759,23760,23758} Loperamide is comparable to morphine in blocking peripheral pain in rats.{23757}

We also advise you