TBCA

TBCA

CAT N°: 14831
Price:

From 55.00 46.75

Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease.{26170,26171} TBCA is a selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases.{24973} It induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity.{24973} TBCA also supports a role for CK2 in platelet function and Akt phosphorylation but not protein splicing.{26172,26173}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2E)-3-(2,3,4,5-tetrabromophenyl)-2-propenoic acid
  • Correlated keywords
    • 1130169-61-7 934358-02-8 inhibitors inhibits inhibitions cancers intracellulars signaling kinases proteins caseins 2 two selective cell-permeable cells permeable CKs CK-2 CK2 death Jurkat adult T T-cells leukemia caspase dependent degradation poly-ADP ribose polymerase II
  • Product Overview:
    Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease.{26170,26171} TBCA is a selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases.{24973} It induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity.{24973} TBCA also supports a role for CK2 in platelet function and Akt phosphorylation but not protein splicing.{26172,26173}

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