BAY 11-<wbr/>7085

BAY 11-7085

CAT N°: 14795
Price:

From 85.00 72.25

In the classical pathway of NF-?B activation, phosphorylation of the inhibitor of NF-?B (I?B?) releases the inhibitor from NF-?B, allowing I?B? degradation and NF-?B activation and nuclear import.{19822} BAY 11-7085 is an irreversible inhibitor of I?B? phosphorylation, preventing activation of NF-?B by cytokines and lipopolysaccharide (IC50 = 10 ?M).{16037} It blocks gene expression that is regulated through the classical pathway of NF-?B activation and in this way blocks apoptosis, cell adhesion, and inflammation.{16037,24580,24840} BAY 11-7085 is also used to study I?B? actions that are independent of NF-?B signaling.{24581}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
  • Correlated keywords
    • inhibits inhibitions inhibitors NF-kB apoptosis inflammation nuclear receptors signals transduction intracellular signaling BAYs 117085 11 7085 BAY-11-7085 BAY11-7085 BAY-117085 BAY117085 BAY11 BAY-11 irreversible I?B? IkBa IkappaBalpha I.kappa.B.alpha. NF-?B NF-kB NF-.kappa.B NF-kappaB genes expressions blocks blockages cells adhesions 117083 phosphorylation cytokines lipopolysaccharides activates activations
  • Product Overview:
    In the classical pathway of NF-?B activation, phosphorylation of the inhibitor of NF-?B (I?B?) releases the inhibitor from NF-?B, allowing I?B? degradation and NF-?B activation and nuclear import.{19822} BAY 11-7085 is an irreversible inhibitor of I?B? phosphorylation, preventing activation of NF-?B by cytokines and lipopolysaccharide (IC50 = 10 ?M).{16037} It blocks gene expression that is regulated through the classical pathway of NF-?B activation and in this way blocks apoptosis, cell adhesion, and inflammation.{16037,24580,24840} BAY 11-7085 is also used to study I?B? actions that are independent of NF-?B signaling.{24581}

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