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13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) and the primary PGE2 metabolite in plasma.{182,2777} It is formed from PGE2 via a 15-keto PGE2 intermediate by 15-oxo-PG ?13 reductase.{2777} Unlike PGE2, 13,14-dihydro-15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 12 and 57 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = >18 and >38 µM, respectively). Levels of 13,14-dihydro-15-keto PGE2 are increased in the plasma of women in the third trimester of pregnancy and in women during and immediately after labor and delivery.{64194} Levels of 13,14-dihydro-15-keto PGE2 levels are decreased in tumor tissue compared to adjacent non-cancerous tissue isolated from patients with non-small cell lung cancer (NSCLC).{64195}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 363-23-5 |
| Molecular formula | C20H32O5 |
| Smiles | O=C1[C@H](C/C=CCCCC(O)=O)[C@@H](CCC(CCCCC)=O)[C@H](O)C1, O=C1[C@H](C/C=CCCCC(O)=O)[C@@H](CCC(CCCCC)=O)[C@H](O)C1, O=C1[C@H](C/C=CCCCC(O)=O)[C@@H](CCC(CCCCC)=O)[C@H](O)C1 |
| Molecular weight | 352,5 |
| Custom code | 2937.50 |
| Formulation | A solution in methyl acetate |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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