Dexrazoxane

Dexrazoxane

CAT N°: 14632
Price:

From 48.00 40.80

Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase II?.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 ?M), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4,4′-[(1S)-1-methyl-1,2-ethanediyl]bis-2,6-piperazinedione
  • Correlated keywords
    • ICRF-187 ICRF187 ICRF 187 doxorubicin cancers cardiotoxicity irons chelators inhibitors inhibits inhibitions topoisomerase II? anthracycline-induced antioxidant free radicals scavengers anthracycline induced induces intracellular reducing reduces reducer cardiotoxicity extravasation injury injuries hydroxyl superoxides lipids DPPH ABTS NSCs 169780 NSC-169780 NSC169780 ADR529 ADRs 529 ADR-529 savene oxidative cardiology 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) diphenylpicrylhydrazyl
  • Product Overview:
    Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase II?.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 ?M), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}

We also advise you