LY2183240 2’-<wbr/>isomer

LY2183240 2’-isomer

CAT N°: 14523
Price:

From 140.00 119.00

LY2183240 (Item No. 10008663) is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis.{14134,15431,16339} It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain.{14134} LY2183240 2’-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.{15431}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
  • Correlated keywords
    • LY2183240 Lys 2183240 LY-2183240 inhibitors inhibits inhibitions anandamides uptakes pains isomers transporters potent competitives small molecules hydrolysis cerebellums 10008663 rats doses dose-dependent efficacy rodents models 2,5-regioisomers forensics cannabinoids
  • Product Overview:
    LY2183240 (Item No. 10008663) is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis.{14134,15431,16339} It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain.{14134} LY2183240 2’-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.{15431}

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