FAK Inhibitor 14

FAK Inhibitor 14

CAT N°: 14485
Price:

From 74.00 62.90

Focal adhesion kinases (FAK) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis.{15630} They are over-expressed in many types of cancer. FAK inhibitor 14 is a direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397 with an IC50 value of about 1 ?M.{23133} There is no known significant effect on the activity of a range of other kinases. FAK inhibitor 14 promotes cell detachment and inhibits cell adhesion of cells in culture.{23133} Moreover, it blocks tumor growth in vivo.{23133,23132,23134} FAK inhibitor 14 has also been used to demonstrate a role for FAK in the regulation of aortic stiffness.{23131}

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