Ac-<wbr/>DEVD-<wbr/>AFC

Ac-DEVD-AFC

CAT N°: 14459
Price:

From 75.00 63.75

During apoptosis, activated caspase-3 cleaves several substrates, including poly(ADP-ribose) polymerase, which it specifically targets at the amino sequence DEVD.{22861} Ac-DEVD-AFC is a fluorogenic substrate for activated caspase-3 (Km = 9.7 µM), as well as related caspases.{22863,6382,22862} Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-acetyl-L-?-aspartyl-L-?-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-?-asparagine
  • Correlated keywords
    • fluorescents fluorescence detections probes enzymes substrates activity apoptosis N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethyl coumarins caspase-3 caspases 3 CPP32 CPP-32 CPP 32 poly ADP adenosine diphosphates riboses polymerases PARP AcDEVDAFC Ac DEVD AFC amino acids sequences free fluorogenic N-Acetyl-Asp-Glu-Val-Asp-AFC
  • Product Overview:
    During apoptosis, activated caspase-3 cleaves several substrates, including poly(ADP-ribose) polymerase, which it specifically targets at the amino sequence DEVD.{22861} Ac-DEVD-AFC is a fluorogenic substrate for activated caspase-3 (Km = 9.7 µM), as well as related caspases.{22863,6382,22862} Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

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