Ac-<wbr/>DEVD-<wbr/>AFC

Ac-DEVD-AFC

CAT N°: 14459
Price:

From 75.00 63.75

During apoptosis, activated caspase-3 cleaves several substrates, including poly(ADP-ribose) polymerase, which it specifically targets at the amino sequence DEVD.{22861} Ac-DEVD-AFC is a fluorogenic substrate for activated caspase-3 (Km = 9.7 µM), as well as related caspases.{22863,6382,22862} Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

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