Thioridazine (hydro<wbr>chloride)

Thioridazine (hydrochloride)

CAT N°: 14400
Price:

From 48.00 40.80

Thioridazine is a typical antipsychotic.{24253} It binds to dopamine D2, histamine H1, M3 muscarinic, and ?1- and ?2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces amphetamine-induced repetitive head bobbing and oral behavior in rats.{46837} It reduces conditioned fear stress-induced freezing behavior in rats when administered at doses ranging from 3 to 100 mg/kg.{46838} Thioridazine is also active against multidrug-resistant tuberculosis in vitro and in vivo.{46839}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine, monohydrochloride
  • Correlated keywords
    • 50-52-2 107388-89-6 mallorol NSC186060 orsanil merlleril melleretten novoridazine ridazin stalleril thioril thiozine Mellaril anti-psychotic ? D 2 H 1 M 3 5HT 1A 2A 2C 6 7
  • Product Overview:
    Thioridazine is a typical antipsychotic.{24253} It binds to dopamine D2, histamine H1, M3 muscarinic, and ?1- and ?2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces amphetamine-induced repetitive head bobbing and oral behavior in rats.{46837} It reduces conditioned fear stress-induced freezing behavior in rats when administered at doses ranging from 3 to 100 mg/kg.{46838} Thioridazine is also active against multidrug-resistant tuberculosis in vitro and in vivo.{46839}

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