Territorial Availability: Available through Bertin Technologies only in France
- Synonyms
- 2-[(3-aminopropyl)amino]-ethanethiol, 1-(dihydrogen phosphate), trihydrate
- Correlated keywords
- 20537-88-6 radiation protections radioprotective cytoprotective cytoprotection hypoxia DNA repairs thiols free radicals scavengers pro drugs p53 activators p21 cells cycles arrests apoptosis prodrugs pro-drugs dephosphorylation alkaline phosphatase active activated WR1065 WRs 1065 WR-1065 scavenging selective reduces reductions reducing toxicity chemo chemotherapeutic agents hydrates WR2721 2721 WR-2721 anifostine trihydrate broad-spectrum broad spectrums therapeutic protective inducing induces expressions normal neoplastic tissues mouse mice fibroblasts cancers cells p53 activates proteins cyclin-dependent cyclins dependents kinases inhibitors inhibits inhibitions p21 arrests G1 G 1 one S G1/S transitions p53-dependent mechanisms
- Product Overview:
Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities.{25648} Because of the differential expression of alkaline phosphatase in normal versus neoplastic tissues, the cytoprotection conferred by amifostine is selective, enabling as much as 100-fold greater accumulation of WR 1065 in normal tissues than in tumor cells.{25648} Amifostine has been used to reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents.{25648} In mouse fibroblasts and various cancer cells, amifostine (IC50 = 4 mM) has been shown to activate p53 protein, to induce the expression of the cyclin-dependent kinase inhibitor p21, and to arrest cells at the G1/S transition through a p53-dependent mechanism.{25649}
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.