8-<wbr/><em>iso</em> Prostaglandin E<sub>2</sub>

8-iso Prostaglandin E2

CAT N°: 14350
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From 83.00 70.55

8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 µg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9-oxo-11?,15S-dihydroxy-(8?)-prosta-5Z,13E-dien-1-oic acid
  • Correlated keywords
    • 8-isoprostanes 8-epi-PGE2 8-iso-PGE2 renal vasoconstriction prostaglandins
  • Product Overview:
    8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 µg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}

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