2-<wbr/>deoxy-<wbr/>D-<wbr/>Glucose

2-deoxy-D-Glucose

CAT N°: 14325
Price:

From 75.00 63.75

2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.{22664,61618} It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.{22666} 2-deoxy-D-glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.{61619,22663} In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).{61620}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-deoxy-D-arabino-hexose
  • Correlated keywords
    • 61-58-5 2092-72-0 3724-71-8 4825-30-3 7640-18-8 glucose analogs hexokinases inhibitors glycolysis hypoxia cancers neurodegeneration calories restriction aging ages non-metabolizable inhibits inhibitions phosphorylations ATP cells cycles deaths hypoxia autophagy ROS reatives oxygen species AMPK tumors growths grows Ba2758 Ba-2758 Bas 2758 NSC15193 NSCs 15193 NSC-15193 61-58-5 2-deoxyglucose D-glucose 2-deoxy-D-mannose 2-deoxy-D-glucose apoptosis adenosines triphosphates proteins glycosylations ER endoplasmic reticulums induces inducing folds folding responses in vitro models blocks blocking animals
  • Product Overview:
    2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.{22664,61618} It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.{22666} 2-deoxy-D-glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.{61619,22663} In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).{61620}

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