GANT 58

GANT 58

CAT N°: 14193
Price:

From 108.00 91.80

Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 58 is a GLI antagonist that inhibits GLI1-mediated transcription (EC50 = 5 ?M) in a variety of cell types.{22122,22692,22693} It inhibits the hh signaling pathway downstream of Smo and the endogenous downstream inhibitor Sufu thereby affecting GLI1 nuclear accumulation.{22122} GANT 58 displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.{22692,22693}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4,4’,4’’,4’’’-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine
  • Correlated keywords
    • 2,3,4,5-Tetra(4-pyridyl)thiophene 94345-01-4 genes regulations cancers Gli hedgehog HH signalling signaling signals inhbitors inhibits inhibitions transcriptions NSC75503 NSC-75503 NSCs 75503 Ewing sarcoma family of tumors ESFTs GANT-58 GANTs 58 antagonists Gli-1 Gli1 cells smoothened Smo endogenous Sufu proteins development Patched vertebrates zinc-finger factors pathways cancers glioblastomas Gli1-mediated downstream nuclear antiproliferatives anti-proliferatives antitumor anti-tumor
  • Product Overview:
    Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 58 is a GLI antagonist that inhibits GLI1-mediated transcription (EC50 = 5 ?M) in a variety of cell types.{22122,22692,22693} It inhibits the hh signaling pathway downstream of Smo and the endogenous downstream inhibitor Sufu thereby affecting GLI1 nuclear accumulation.{22122} GANT 58 displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.{22692,22693}

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